Endocrine Abstracts

Introduction: One goal of diabetic regenerative medicine is to instructively convert mature pancreatic exocrine cells into insulin-producing cells. We recently reported that liganded thyroid hormone receptor α (TRα) plays a critical role in expansion of the β-cell mass during postnatal development.Materials and Methods: AdTRα is a recombinant adenoviral vector that expresses human TRα1 under the control of the cytomegalovirus pro...